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Providers > Researchers > Kathryn Haskins
T cell immunology, autoimmunity, type 1 diabetes. Our research is focused on the mechanisms and regulation of pathogenesis in the NOD mouse model of type 1 diabetes (T1D). We use cloned T cell lines and TCR transgenic mice to study the disease process. Our goals are to acquire better understanding of how CD4 T cells contribute to pathogenesis in T1D, investigate the beta cell autoantigens that activate autoreactive T cells, and develop new strategies for inducton of tolerance and prevention of disease.
Professor, Department of Immunology
AAI, American Diabetes Association, Immunology of Diabetes Society
Haskins, K. 2005. Pathogenic T cell clones in autoimmune diabetes: more lessons from the NOD mouse. Advances in Immunol. 87: 123-62.
Cantor, J. and Haskins, K. (2005) Effector Function of Diabetogenic CD4 Th1 T cell clones: A Central Role for TNFa. J. Immunol. 175: 7738-45.
Cantor, J. and Haskins, K. (2007) Recruitment and activation of macrophages by pathogenic CD4 T cells in T1D: Involvement of CCR8 and CCL1. J. Immunol. 179: 5760-67. Tonkin, D.R., He, J., Barbour, G. and Haskins, K. 2008. Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J. Immunol. 181: 4516-22
Tonkin, D.R. and Haskins, K. 2009. Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-ß-dependent manner. Eur. J. Immunol. 39: 1313-22.
Stadinski, B.D.*, Delong, T.*, Reisdorph, N., Reisdorph, R., Powell, R.L., Armstrong, M., Piganelli, J.D., Barbour, G., Bradley, B., Crawford, F., Marrack, P., Mahata, S.K., Kappler, J.W. and Haskins, K. 2010. Chromogranin A is an autoantigen in type 1 diabetes. Nature Immunology 11: 225-31.
*Denotes equal contributions.
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