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Publications

The following abstracts and posters were presented at the CounterAct Meeting in April, 2007


  1. CEES (2-Chloroethyl Ethyl Sulfide) inhalation: Disruption and adaption in sulfur metabolism.  Raymond C. Rancourt1, Heidi C. O’Neill1, Glen S. McConville1, Joan Loader1, Justin Hinde1, Sally J. Stabler2, Carl W. White1, and Brian J. Day1     1National Jewish Health, Denver, Colorado;2University of Colorado Denver, Denver Colorado.
  2. Inhalation of 2-chloroethyl ethylsulfide (CEES; half-mustard) causes necrotizing bronchiolitis.  O’Neill HC, Loader JE, Hinde JL, Rancourt RC, McConville GS, White CW. National Jewish Health, Denver, CO 80206.
  3. Glutathione protection against toxicity of 2-chloroethyl ethylsulfide (CEES; half mustard) in human airway epithelial cells . Tara N. Jones#, Raymond C. Rancourt #, Heidi C. O’Neill*, Brian J. Day#, and Carl W. White # *    # National Jewish Health 1400 Jackson Street Denver, CO 80206    *Department of Pharmaceutical Sciences, Program in Toxicology University of Colorado Denver 4200 E 9th Avenue, C-238 Denver, CO 80262
  4. Characterization of a system for airway delivery of 2-chloroethyl ethylsulfide (CEES; half-mustard).   McConville G, Van Dyke M, Martyny J, Rancourt RC, O’Neill H, White CW, Day BJ, and R Jaeger.  National Jewish Health, Denver, CO 80206, and CH Technologies (CHT), Westwood, NJ 07675, USA.

 

The following have been submitted for presentation at the Society of Toxicology (SOT) meeting for 2007

 

  1. Sulfur mustard analog-caused activation of signaling cascades in SKH-1 hairless mouse skin.  A. Pal, C. Agarwal, S. Rana, M. Gu, N. Tewari-Singh, C.W. White* and R. Agarwal.  University of Colorado Denver, Denver, CO; *National Jewish Health, Denver, CO.
  2. Biological and molecular markers for sulfur mustard analog CEES-induced skin injury in mouse and human epidermal keratinocytes.  N. Tewari-Singh, S. Rana, M. Gu, C. Agarwal, C.W. White* and R. Agarwal.  University of Colorado Denver, Denver, CO; *National Jewish Health, Denver, CO.
  3. Developing in vivo CEES-induced skin toxicity mouse models.  Rana S, Tewari-Singh N, Mallikarjuna GU, Orlicky DJ, *White CW, and Agarwal R.  University of Colorado Denver, Denver, CO; *National Jewish Health, Denver, CO

 

Other significant publications related to our research

 

  1. Bifunctional Alkylating Agent-Induced p53 and Nonclassical Nuclear Factor kB Responses and Cell Death Are Altered by Caffeic Acid Phenethyl Ester: A Potential Role for Antioxidant/Electrophilic Response-Element Signaling.   Minsavage GD and Dillman III, JF.   The Journal of Pharmacology and Experimental Therapeutics 2007,321:202-212.
  2. Genomic Analysis of Rodent Pulmonary Tissue Following Bis-(2-chloroethyl) Sulfide Exposure. Dillman III, JF, Phillips CS, Dorsch LM, Croxton MD, Hege AI, Sylvester AJ, Moran TS, Sciuto AM.   Chem Res Toxicol. 2005,18:28-34.
  3. MALDI-ToF/MS as a Diagnostic Tool for the Confirmation of Sulfur Mustard Exposure.  Price EO, Smith, JR, Clark CR, Schlager JJ, Shih ML.   J Applied Toxicology.  2000,20:S193-S197.
  4. The Sources, Fate, and Toxicity of Chemical Warfare Agent Degradation Products.  Munro NB, Talmage SS, Griffin GD, Waters LC, Watson AP, King JF, Hauschild V.  Environmental Health Perspectives. 1999,107:933-974.
  5. Modulation of the Expression of Superoxide Dismutase Gene in Lung Injury by 2-Chloroethyl Ethyl Sulfide, a Mustard Analog.  Mukhopadhyay S, Rajaratnam V, Mukherjee S, Smith M, Das SK.   J Biochem Molecular Toxicology. 2006,20:142-149.
  6. Pretreatment of Human Epidermal Keratinocytes with D, L-Sulforaphane Protects Against Sulfur Mustard Cytotoxicity.  Gross CL, Nealley EW, Nipwoda MT, Smith WJ.  Cutaneous and Ocular Toxicology. 2006,25:155-163.
  7. Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes.  Kumar O, Sugendran K, Vijayaraghavan R.    Chemico-Biological Interactions.  2001,134:1-12.
  8. Microarray Analysis of Mouse Ear Tissue Exposed to Bis-(2-chloroethyl) Sulfide: Gene Expression Profiles Correlate with Treatment Efficacy and An Established Clinical Endpoint.  Dillman III JF, Hege AI, Phillips CS, Orzolek LD, Sylvester AJ, Bossone C, Henemyre-Harris C, Kiser RC, Choi YW, Schlager JJ, Sabourin CL.   Journal of Pharmacology and Experimental Therapeutics.  2006,317:76-87.
  9. Modifications of breathing pattern induced by inhaled sulphur mustard in mice.  Vijayaraghavan R.    Arch Toxicol. 1997,71:157-164.
  10. Calmodulin mediates sulfur mustard toxicity in human keratinocytes.  Simbulan-Rosenthal CM, Ray R, Benton B, Soeda E, Daher A, Anderson D, Smith WJ, Rosenthal DS.    Toxicology. 2006,227:21-35.
  11. Wound Healing of Cutaneous Sulfur Mustard Injuries: Strategies for the Development of Improved Therapies.   Graham JS, Chilcott RP, Rice P, Milner SM, Hurst CG, Maliner BI.    Journal of Burns and Wounds.  2005,4:1-45.

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